A multifaceted analysis of OTUD5 integrated MAVS in innate immunity of Primary Biliary Cholangitis.

ABSTRACT:

Background

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by cholestasis caused by intrahepatic small bile duct injury. Promoting the molecular mechanism of OTU deubiquitinase 5 (OTUD5) in the treatment of PBC requires further exploration. This study unraveled the molecular underpinnings of PBC through bio-informatics analysis and experimental verification for the development of targeted therapeutic strategies.

Methods

This study screened immune-related genes and validated their expression patterns in whole blood of patients with PBC using microarray based on GEO datasets. The expression level of OTU deubiquitinase 5 (OTUD5) was validated in peripheral blood samples using RT-qPCR and immunofluorescence. Subsequently, proteomic bioinform

SUBMITTER: Chen R 

PROVIDER: S-EPMC12880646 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature