Vancomycin variable Enterococci in the Netherlands (2018-2023) and the mechanism of resistance induction.

ABSTRACT: Enterococci are common human commensals but can cause severe infections in immunocompromised patients. Enterococcus faecium is a notable example, capable of acquiring resistance to multiple antibiotics, including the critically important drug vancomycin. Such strains, known as vancomycin-resistant E. faecium (VRE), are routinely detected in clinical laboratories using phenotypic assays. However, some isolates carry vancomycin resistance genes yet remain phenotypically susceptible; these are termed vancomycin variable enterococci (VVE). Because phenotypic assays may fail to identify VVE, patients treated with glycopeptides risk developing undetected VRE infections. VVE have been reported in Scandinavia and Japan, but their prevalence in the Netherlands remains largely unknown. To address th

SUBMITTER: von Wintersdorff CJH 

PROVIDER: S-EPMC12880688 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature