Combined R2R3-MYB transcription factor mutants reveal the regulatory structure of the Arabidopsis thaliana flavonoid biosynthesis pathway.

ABSTRACT:

Main conclusion

Comparative metabolic profiling of new genetic multiple flavonoid r2r3-myb mutants show that different types of R2R3-MYBs activate the early flavonoid biosynthesis genes. A revised model for flavonoid biosynthesis in Arabidopsis thaliana is proposed that integrates the regulatory roles of these R2R3-MYBs across early and late biosynthetic steps. Flavonoids are a large group of specialized plant metabolites. Their biosynthesis is mainly transcriptionally regulated by a sophisticated network of different transcription factors from various families, with R2R3-MYB factors being the main determinant of specific flavonoid class formation. The early biosynthetic steps, leading to the formation of non-visible flavonoids, have been proposed to be regulated by three R2R3-MYBs

SUBMITTER: Sielmann LM 

PROVIDER: S-EPMC12881018 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature