The Biosynthetic Gene Cluster of Boydines in Scedosporium apiospermum.

ABSTRACT: Although Scedosporium species may cause severe infections in immunocompromised patients, little is known about their pathogenic mechanisms. The thioredoxin reductases (TrxRs) of Scedosporium apiospermum are thought to play an important role in protecting the fungus against oxidative stress. The genes that encode these proteins are part of biosynthetic gene clusters (BGCs) which ensure the synthesis of non-ribosomal peptides. Due to the discrepancies between chemical studies and bioinformatic predictions regarding the product of the BGC comprising the TrxR-encoding gene SAPIO_CDS1830, a large-scale study of almost 300 fungal genomes was undertaken to search for BGCs that could potentially synthesize homodipeptides. Phylogenetic analysis of the amino acid sequence of the adenylation domain o

SUBMITTER: Carvalho C 

PROVIDER: S-EPMC12881047 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature