Developmental Cascades From Prenatal Tobacco, Tobacco-cannabis Co-exposure to Early school-age externalizing Problems.

ABSTRACT: Prenatal tobacco (PTE) and tobacco cannabis co-exposure (PTCE) are associated with higher risk for child externalizing problems. However, developmental mechanisms for the PTE association and the PTCE related associations are poorly understood. We tested multiple mechanistic developmental pathways (emotion regulation, temperament, maternal negative mood, and continued postnatal tobacco exposure) from PTE and PTCE to early school age externalizing problems. The sample consisted of 293 diverse (48% Black, 27% White, 14% Hispanic, and 11% other or mixed race; 64.8% WIC recipients) mother-child dyads grouped as: PTE (n = 89; 62.92% male), PTCE (n = 105; 47.62% male), and demographically similar non-substance-exposed mother-child dyads (n = 99; 43.43% male). Substance exposure was assessed using

SUBMITTER: Perry KJ 

PROVIDER: S-EPMC12881090 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature