Multimodal molecular mechanisms of octanoic acid (OA) against recurrent mastitis causing pathogens.

ABSTRACT: Recurrent bovine mastitis is a global concern that causes substantial economic losses and is exacerbated by pathogen internalization into mammary epithelial cells, and the emergence of antimicrobial resistance. These challenges necessitate the development of alternative antimicrobial strategies with multimodal activity. In this study, the naturally occurring molecule octanoic acid (OA) was evaluated for its antimicrobial efficacy and multitargeted mode of action against mastitis-associated pathogens. OA exhibited rapid bactericidal activity within 1 h and significantly reduced bacterial pathogenicity by attenuating toxin activity and inhibiting pathogen adhesion and internalization into epithelial cells. Transcriptomic analysis of Staphylococcus aureus revealed extensive OA-induced transcr

SUBMITTER: Hsu KC 

PROVIDER: S-EPMC12881107 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature