Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease.

ABSTRACT:

Aims/hypothesis

Ferroptosis, a regulated form of cell death characterised by excessive lipid peroxidation, plays a critical role in acute kidney injury (AKI). Individuals with diabetes have an elevated risk of developing AKI. However, the contribution of ferroptosis to the heightened susceptibility to AKI in diabetic kidney disease (DKD) remains unclear. This study aimed to investigate whether DKD influences ferroptosis susceptibility in proximal tubular epithelial cells (PTECs), focusing on autophagy and AMP-activated protein kinase (AMPK) signalling.

Methods

We examined the association between ferroptotic signatures and autophagy/AMPK pathways in human kidney biopsy specimens. To explore the roles of autophagy and AMPK in modulating ferroptosis in PTECs during DKD, we subj

SUBMITTER: Matsui S 

PROVIDER: S-EPMC12881128 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature