The nonsense-mediated mRNA decay factor Upf3 negatively regulates bulk autophagy progression in <i>Saccharomyces cerevisiae</i>.

ABSTRACT: Macroautophagy/Autophagy is a highly conserved mechanism that targets cytoplasmic cargo for degradation and recycling. At present, 45 autophagy-related (ATG) genes have been identified in fungi. Due to this complexity, the autophagy pathway must be strictly regulated at multiple levels (transcriptional, post-transcriptional, translational, and post-translational). Dysregulation of autophagy can have detrimental effects on cell health and survival. Therefore, investigation into the mechanisms regulating autophagy is critical. The nonsense-mediated mRNA decay (NMD) pathway targets transcripts with premature translation termination codons (PTCs), although NMD also regulates normal transcripts. NMD requires conserved factors in yeast - Upf1, Upf2, and Upf3. Here, we demonstrate that aut

SUBMITTER: Tasmi TA 

PROVIDER: S-EPMC12885402 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature