Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions.

ABSTRACT:

Purpose

Neurocognitive impairments are a core feature of psychosis and impact long-term outcomes. While sex differences in neurocognition have been observed in first-episode psychosis (FEP), findings remain mixed, and little is known about differential responses to metacognitive interventions. This study examined sex differences in the effectiveness of Metacognitive Training (MCT) on neurocognitive outcomes in FEP.

Methods

A total of 122 individuals with FEP were randomized to receive either MCT or psychoeducational intervention. Neurocognitive performance was assessed at baseline and at 6-month follow-up using a comprehensive battery (CPT-II, TMT, WCST, Stroop test, TAVEC, WAIS-III Digit Span). General Linear Models tested the effects of intervention, sex, and their interac

SUBMITTER: Verdaguer-Rodriguez M 

PROVIDER: S-EPMC12886316 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature