Investigating associations between serum inflammatory cytokines at the time of second mild traumatic brain injury with acute neurological signs, axonal injury and behavioural outcomes in male Sprague-Dawley rats.

ABSTRACT: Mild traumatic brain injury is a risk factor to sustaining future mild traumatic brain injuries and increased symptom severity and duration following a second mild traumatic brain injury. Inflammation during neurobiological recovery is hypothesized to influence susceptibility to poorer outcomes after repetitive mild traumatic brain injury. Here, we investigated whether the inflammatory response during neurobiological recovery is related to susceptibility to increased functional and biological deficits following re-injury. To investigate this, we collected serum 1, 3, 7 or 14 days after mild traumatic brain injury in male Sprague-Dawley rats and measured levels of circulating inflammatory cytokines using the MesoScale Discovery MESO QuickPlex SQ 120MM platform to quantify interferon-gamma,

SUBMITTER: Brand J 

PROVIDER: S-EPMC12887899 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature