<i>Arginine Kinase 1</i> regulates energy homeostasis in <i>Drosophila</i> muscle development.

ABSTRACT: In Drosophila, Arginine kinase 1 (Argk1) is involved in maintaining ATP homeostasis during bursts of activity in tissues with high and variable rates of energy turnover such as muscle. However, its role beyond stress conditions is less understood. Here, we show that Argk1 maintains energy homeostasis during flight muscle development and is required for animal viability and proper muscle function. The knockdown of Argk1 causes defects in both early and late stages of myogenesis. In the proliferating myoblasts associated with the wing disc, Argk1 depletion results in a reduction in cell size without changes in cell cycle progression. Single cell RNA-sequencing revealed that the overall composition of differentiating and undifferentiating myoblasts is not altered. Nonetheless, A

SUBMITTER: Zappia MP 

PROVIDER: S-EPMC12889440 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature