Connectomes across temporal scales with simultaneous wide-field optical imaging and resting-state functional MRI.

ABSTRACT: Resting-state functional MRI (rs-fMRI) is a cornerstone of human brain research, yet its interpretation is complicated by its sensitivity to the slow hemodynamic response that obscures the organization of neural activity across faster time scales. Here we use simultaneous wide-field optical imaging (WOI) and rs-fMRI to directly examine the relationship between neural and hemodynamic functional connectomes across time scales. We show that much of the large-scale spatial structure is preserved across modalities, across time scales, and across frequencies. Although rs-fMRI robustly captures time-averaged neural activity, time-resolved rs-fMRI estimates of functional connectivity exhibit significantly greater variability, which partially reflects sensitivity limitations. Hemodynamic WOI signal

SUBMITTER: Pan WJ 

PROVIDER: S-EPMC12889463 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature