Cellular diversity of the developing chick trigeminal ganglion at single-cell resolution.

ABSTRACT:

Background

The trigeminal ganglion (TG) is a structure of the peripheral nervous system, composed of neuronal and non-neuronal cell types, that integrates sensory input from the face and jaw. The developing TG is derived from two embryonic cell populations: neural crest and cranial placode. Both populations play critical roles in TG development and must interact to coordinate changes in gene expression that regulate specification, differentiation, and organization. However, the molecular characteristics of the heterogeneous cell populations within the developing TG remain poorly defined.

Results

We performed single-cell RNA-sequencing (scRNA-seq) on TG from developing chick embryos at HH17. Our high-resolution dataset (14 clusters, ~87000 cells) provides insight into cellula

SUBMITTER: Rajan AAN 

PROVIDER: S-EPMC12889475 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature