Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell Receptors.

ABSTRACT: Virus-specific CD8⁺ T cells are crucial in controlling chronic human viral infections such as HIV-1, but the effect of persistent antigen exposure on T cell repertoire formation is not well understood. In this study, we examined epitope-specific CD8⁺ T cell repertoires in people living with HIV-1, where duration of viremia following hyperacute infection was modulated by the time of initiation of continuous suppressive antiretroviral therapy (ART). After ART-induced undetectable viremia in persons expressing the same HLA class I allele, we analyzed the impact of early (n=6) versus delayed (n=6) ART initiation on the clonotypic composition, clonotypic cross-reactivity, functional avidity and memory differentiation profile of the HIV-specific T cell repertoire restricted

SUBMITTER: Ogunshola FJ 

PROVIDER: S-EPMC12889509 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature