Distinct cortical excitability and connectivity profiles within the human SMA complex.

ABSTRACT:

Introduction and aim

Understanding brain functions increasingly relies on a network-based perspective, emphasizing interactions across distributed regions. High-order cognitive functions, like language and executive processes, engage such networks rather than isolated cortical areas, yet mapping their dynamics in humans remains challenging. The supplementary motor area (SMA) complex serves as a crucial hub, functioning as an interface between cognitive and sensorimotor processing. Navigated transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) enables causal, time-resolved assessment of cortical excitability and connectivity with high temporal and spatial precision. Extending prior proof-of-concept work, this study aims to provide normative neurophysiolog

SUBMITTER: Lomi F 

PROVIDER: S-EPMC12889535 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature