Nanocellulose hydrogels as bio-interface analogs for studying nanomaterial transport and accumulation.

ABSTRACT: Nanomaterials have been proposed as drug delivery vehicles to enhance targeting and efficiency of traditional and novel therapeutics and have subsequently been studied for potential ecotoxicity. Previous studies have identified size, surface charge, and volume exclusion as factors that influence nanomaterial diffusion and retention. However, there is little accepted or successful quantification of how these parameters influence nanomaterial penetration relative to biological adaptation and biological response. Part of the challenge is the response of living biological interfaces to many of these nanomaterial delivery vehicles and nanosized drugs. This study aimed to emulate key physicochemical barriers to diffusion found in living biomaterials by developing a tunable, synthetic hydrogel. T

SUBMITTER: Prince J 

PROVIDER: S-EPMC12889593 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature