Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons.

ABSTRACT: The action potential (AP) is thought to be generated at the axon initial segment and to faithfully propagate along the axon. However, data from both invertebrate and mammalian systems show that the axon is an underappreciated locus of activity modulation and neuronal computation. We assessed axonal AP propagation in neocortical parvalbumin-expressing interneurons (PV-INs) during prolonged, high-frequency activity through paired whole-cell somatic and axon-attached patch clamp recordings in acute brain slices from mouse and human. We found that PV-IN axonal AP propagation remains robust during prolonged activity at moderate frequencies, such as during the entrainment to PV-IN firing patterns recorded in awake, behaving mice in vivo. However, prolonged, high-frequency activity during

SUBMITTER: Liebergall SR 

PROVIDER: S-EPMC12889714 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature