Population genomics of <i>Drosophila pseudoobscura</i>.

ABSTRACT: Drosophila pseudoobscura is a long-standing model organism in evolutionary genetics because natural populations segregate for an inversion polymorphism on the third chromosome. In addition, D. pseudoobscura has a neo-X chromosome that was formed by an X-autosome fusion, which segregates for a sex-ratio drive allele. Previous genome-wide studies of DNA sequence variation in D. pseudoobscura have focused on individual chromosomes or did not use chromosome-scale reference genomes. To address these shortcomings, we generated a new D. pseudoobscura population genetic resource by sequencing the genomes of over 60 inbred lines sampled across the species' geographic range in North America. Using these data, we examined patterns of nucleotide diversity and population str

SUBMITTER: Manat Y 

PROVIDER: S-EPMC12889741 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature