Multi-omics Insight into Cardiac Myofibril Remodeling in Post-Prandial Burmese Pythons.

ABSTRACT: Burmese pythons exhibit rapid cardiac remodeling in response to a dramatic increase in metabolic rate during digestion. Here, we performed single-myofibril mechanics measurements and myosin heavy chain metabolic assays to evaluate the impact of feeding on the cardiomyocyte sarcomere - the fundamental molecular unit of muscle contraction - using two experimental paradigms: normal feeding (one meal per month) and frequent feeding (eight meals per month). Myofibril tension and rate of relaxation increased during digestion in both paradigms, while frequent feeding was further associated with slower myofibril activation kinetics and faster myosin heavy chain ATP turnover. To identify molecular changes at the sarcomere and gain potential mechanistic insight, we performed multi-omics analyses. RN

SUBMITTER: Martin TG 

PROVIDER: S-EPMC12889742 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature