Estimating enteric fever seroincidence in rural western Cambodia: findings from a population-based cross-sectional serosurvey.

ABSTRACT:

Introduction

Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi, remains an important cause of febrile illness in low- and middle-income countries (LMIC). However, the exact burden is difficult to estimate due to limitations in diagnosis and surveillance.

Methods

Samples from a representative cross-sectional household serosurvey in rural western Cambodia were used to estimate enteric fever seroincidence among children and young adults. Participants were enrolled between April 7 and December 10, 2023, and 529 samples from individuals aged 5-25 years were analysed. Using IgA and IgG responses to hemolysin E antigen and established models of antibody decay after infection, we estimated seroincidence, conveying the rate of new infection in the popul

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12889769 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature