Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency.

ABSTRACT:

Background

Primary amoebic meningoencephalitis (PAM) is a rapidly progressive and often fatal central nervous system infection caused by Naegleria fowleri. Despite widespread environmental exposure to this free-living amoeba, clinical disease is rare, suggesting that it requires not only exposure to the amoeba but also a host vulnerability. Yet, the immune mechanisms controlling protection vs. susceptibility to N. fowleri remain poorly understood.

Methods

We conducted comprehensive clinical, immunological, and genetic investigations in one of the few survivors of PAM. We performed high-dimensional immune profiling using Cytometry by Time-Of-Flight (CyTOF) to assess immune cell composition and activation state. We employed whole-exome sequencing (WES) to identif

SUBMITTER: Cui J 

PROVIDER: S-EPMC12889776 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature