Prenatal Alcohol Exposure and Mental Health Outcomes: A Two-Sample Mendelian Randomization Study of DNA Methylation Signatures.

ABSTRACT: Prenatal alcohol exposure (PAE) can lead to a range of deficits falling under the umbrella of Fetal Alcohol Spectrum Disorder (FASD), which included higher risk for adverse neurodevelopmental and mental health outcomes. Although the biological mechanisms underlying the link between PAE and mental health remain unclear, DNA methylation (DNAm), an epigenetic modification responsive to environmental exposures, may explain these relationships. Here, we applied a two-sample Mendelian randomization (MR) framework to assess whether DNAm loci previously associated with PAE or FASD are linked to 11 psychiatric outcomes. Using summary statistics from the Genetics of DNA Methylation Consortium (GoDMC) mQTL database and large-scale GWAS, we analyzed DNAm loci from two epigenome-wide association studie

SUBMITTER: Luo D 

PROVIDER: S-EPMC12889801 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature