Multi-model Diffusion MRI Signatures in Atypical Parkinsonian Disorders.

ABSTRACT: Distinguishing atypical parkinsonian disorders (APS) from Parkinson's disease (PD) remains challenging due to overlapping clinical features, yet accurate differentiation is critical for prognosis and treatment. Here, we employed multi-model diffusion MRI (dMRI) analysis to characterize microstructural alterations across corticobasal syndrome (CBS), progressive supranuclear palsy-Richardson syndrome (PSP-RS) and PD, with the aim of identifying which dMRI model provides optimum differentiation. We analyzed 25 CBS, 42 PSP-RS, and 21 PD participants compared to 35 age and sex-matched controls. Using a clinically feasible 3-shell high angular resolution diffusion imaging (HARDI) protocol, we applied 11 metrics from five complementary dMRI models-diffusion tensor imaging (DTI), free-water-elimin

SUBMITTER: Tian Y 

PROVIDER: S-EPMC12889870 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature