Aging syndrome genes and premature coronary artery disease.

ABSTRACT:

Background

Vascular disease is a feature of aging, and coronary vascular events are a major source of morbidity and mortality in rare premature aging syndromes. One such syndrome is caused by mutations in the lamin A/C (LMNA) gene, which also has been implicated in familial insulin resistance. A second gene related to premature aging in man and in murine models is the KLOTHO gene, a hypomorphic variant of which (KL-VS) is significantly more common in the first-degree relatives of patients with premature coronary artery disease (CAD). We evaluated whether common variants at the LMNA or KLOTHO genes are associated with rigorously defined premature CAD.

Methods

We identified 295 patients presenting with premature acute coronary syndromes confirmed by angiography. A control grou

SUBMITTER: Low AF 

PROVIDER: S-EPMC1289285 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature