Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia.

ABSTRACT: The basal ganglia play essential roles in motor control, emotion, learning and reward processing. Their dysfunction contributes to many neurological and psychiatric disorders. However, the gene regulatory programs defining basal ganglia cell-type identity and function remain poorly understood, limiting interpretation of disease-associated non-coding variants. Here, we present the first single-cell multiome atlas of histone modifications and transcriptomes across eight basal ganglia regions from neurotypical adult human donors. Joint profiling reveals cell-type-specific deployment of active and repressive cis -regulatory elements and gene regulatory networks, and suggests a combinatorial homeobox transcription factor code underlying cell identity. Integration with matched spatial tra

SUBMITTER: Chang L 

PROVIDER: S-EPMC12893060 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature