Genetic liability to addiction underlies comorbid bipolar and substance use disorders.

ABSTRACT:

Background

Bipolar disorder (BIP) frequently co-occurs with heightened substance use (SU) and substance use disorders (SUDs). Although the strong co-occurrence of these heritable traits points to shared genetic susceptibility, the extent to which there are differences in how SU and SUD overlap with BIP genetic architecture remains unclear.

Methods

We quantified the polygenic overlap between BIP and SUDs (alcohol, cannabis, opioid, and tobacco), and BIP and SU traits (drinks per week, lifetime cannabis use, prescription_opioid use, and smoking initiation) using GWAS summary statistics and trivariate MiXeR. We then isolated the general and unique genetic contributions of SUD and SU using GWAS-by-subtraction via GenomicSEM. Next, we tested associations between polygenic risk sc

SUBMITTER: Ystaas LAR 

PROVIDER: S-EPMC12893063 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature