Natural Killer Cell Dysregulation During ALS Disease Progression: A Gene Expression Analysis.

ABSTRACT:

Background and objectives

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative motor neuron disease with a pathophysiology that features dysregulated natural killer (NK) cells that are capable of damaging neurons. Although NK cells are associated with ALS progression and survival, their specific characteristics and how these characteristics change over the course of disease is unknown. The current study examines NK cell gene expression during ALS with the goal of identifying dysregulated genes and pathways in NK cells over the course of disease in order to identify potential new therapeutic targets.

Methods

ALS participants with an El Escorial ALS diagnosis were recruited from the University of Michigan Pranger ALS Clinic, and control participants

SUBMITTER: Goutman SA 

PROVIDER: S-EPMC12893619 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature