Anti-obesity effects of <i>Withania somnifera</i> and <i>Chrysanthemum zawadskii</i> Herbich var. <i>latilobum</i> (Maxim.) Kitamura by regulating lipid metabolism and insulin signaling in 3T3-L1 adipocytes.

ABSTRACT:

Background/objectives

Obesity is a complex metabolic disorder characterized by excessive adipose tissue accumulation, dysregulated lipid metabolism, and insulin resistance, leading to an increased risk of metabolic disease. While Withania somnifera (AS) and Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura (C) have traditionally been used for their metabolic regulatory properties, their combined effects on adipogenesis, lipogenesis, lipolysis, and insulin signaling remain unexplored. Therefore, this study aimed to evaluate the anti-obesity effects of AS, C, and their optimal combination (ASC) in 3T3-L1 adipocytes by investigating their impact on lipid metabolism and glucose homeostasis.

Materials/methods

Following adipogenic differentiatio

SUBMITTER: Park SH 

PROVIDER: S-EPMC12893852 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature