[⁶⁸Ga]Ga-DOTATATE PET/CT and PET/MR enhances the detection of pituitary ACTH-secreting adenomas in cushing's disease.

ABSTRACT:

Introduction

This study aimed to evaluate the diagnostic performance of [⁶⁸Ga]Ga-DOTATATE PET/CT or PET/MR in comparison to dynamic MR (dMR) in locating ACTH-secreting pituitary adenomas in Cushing's disease (CD). The utility of PET and MR semi-quantitative parameters was additionally explored as non-invasive biomarkers for tumor characterization.

Methods

Aretrospective analysis was conducted in 14 patients with CD and 16 controls with ectopic ACTH syndrome. Surgical pathology and post-operative follow-up served as reference standard. All patients underwent [⁶⁸Ga]Ga-DOTATATE PET/CT or PET/MR, dMR; some also underwent [¹⁸F]F-FDG PET. Imaging interpretation included visual and semi-quantitative (SUVmax and ADCmin) assessment.

Results

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SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12893962 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature