Pathologic response and safety of preoperative treatment regimens in gastric cancer undergoing D2 gastrectomy: a real-world cohort study.

ABSTRACT:

Objective

To compare pathological response and safety among three preoperative treatment regimens-chemotherapy alone, chemotherapy plus immunotherapy, and chemotherapy plus immunotherapy and targeted therapy-in gastric cancer undergoing D2 gastrectomy, and to assess biomarker associations with response.

Methods

We retrospectively included 195 patients who received preoperative systemic therapy followed by D2 gastrectomy: chemotherapy alone (n = 47), chemotherapy plus immunotherapy (n = 100), or chemotherapy plus immunotherapy and targeted therapy (n = 48). Preoperative therapy was considered neoadjuvant for cM0 disease and conversion therapy for selected baseline cM1 disease. The primary endpoint was MPR (including pCR). pCR was also reported separately as a subset of MPR; s

SUBMITTER: Liu P 

PROVIDER: S-EPMC12893969 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature