Dahuang gancao dandelion decoction regulates intestinal flora and inhibits NF-κB/ARA signaling pathway to alleviate ulcerative colitis.

ABSTRACT:

Objective

The aim of this study was to assess the therapeutic effects and underlying mechanisms of Dahuang Gancao Dandelion Decoction (DGD-D) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in a mice model, with an emphasis on modulation of gut microbiota and intestinal metabolites, maintenance of intestinal barrier integrity, and inhibition of inflammatory signaling pathways.

Methods

Ultra-high-performance liquid chromatography with quadrupole electrospray ionization mass spectrometry (UHPLC-QE-MS) was used to examine the DGD-D, which was prepared from 40 g rhubarb, 10 g licorice, and 10 g dandelion. Potential routes and targets were found using network pharmacology. Six male C57BL/6 mice per group were randomized into control, DSS, DGD-D, and mesalazine (5-

SUBMITTER: Malajiang X 

PROVIDER: S-EPMC12893983 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature