Optimizing mature oocyte yield in IVF: clinical comparison of r-hFSH+r-hLH and HMG in women with a stimulation dosage of at least 300 IU of gonadotropins.

ABSTRACT:

Objective

To study the impact of luteinizing hormone (LH) in stimulation medication on the mature oocyte yield obtained in in women receiving ovarian stimulation (OS) with a dosage of at least 300 IU gonadotropins.

Design

Retrospective cohort study (01/2016-05/2024).

Setting

Tertiary assisted reproductive technology center.

Patients

Women undergoing OS stimulation of at least 300 IU gonadotropins.

Intervention

OS using r-hFSH+r-hLH or HMG as stimulation medication.

Main outcome measure

Retrieved mature oocyte number.

Results

A total of 1,286 patients (696 in the HMG group and 590 in the r-hFSH+r-hLH group) were included in the unmatched cohort. Before matching, the r-hFSH+r-hLH versus HMG-groups showed significant differences in AMH (0.8 vs

SUBMITTER: Fatemi H 

PROVIDER: S-EPMC12893992 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature