The incidence of chronic drug-induced liver injury: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Drug-induced liver injury (DILI) is a recognized adverse drug event. Although most cases present with acute hepatic damage, evidence indicates that a proportion progress to persistent liver injury. The absence of a standardized definition for chronic DILI has contributed to significant discrepancies in reported incidence rates across clinical studies. This meta-analysis aims to determine the pooled incidence of chronic DILI, providing robust epidemiological evidence.

Methods

This meta-analysis was conducted in accordance with the PRISMA and MOOSE guidelines. A systematic search was conducted in PubMed, Web of Science, Embase and Cochrane Library databases from their respective inception dates to 11 July 2025. The quality of cohort studies was assessed using the NO

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12893995 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature