The importance of staying within range: associations between tacrolimus intrapatient variability and kidney transplant outcomes.

ABSTRACT:

Background

Kidney transplantation remains the treatment of choice for end-stage kidney disease. Maintaining immunosuppression within the appropriate therapeutic range is essential to prevent rejection and ensure long-term graft survival. This study evaluated the clinical relevance of different tacrolimus exposure metrics and their association with post-transplant outcomes in a real-world kidney transplant cohort.

Methods

Of 881 adult deceased-donor kidney transplants performed between 2011 and 2020 at Heidelberg University Hospital, 372 recipients with a functioning graft at day 180 met the inclusion criteria and were included in the final analysis. Tacrolimus trough levels between days 90 and 180 were used to calculate different exposure metrics, including intrapatient vari

SUBMITTER: Benning L 

PROVIDER: S-EPMC12894007 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature