Elevated thymidine kinase 1 expression at baseline predicts poor prognosis in breast cancer patients.

ABSTRACT:

Introduction

Thymidine kinase 1 (TK1), a key enzyme in DNA biosynthesis, has been shown to correlate with breast cancer prognosis and treatment response in dynamic monitoring settings. However, the clinical relevance of baseline TK1 levels remains controversial due to inconsistent evidence across studies. To address this issue, we conducted the first systematic meta-analysis of available studies to investigate the potential association between baseline TK1 levels and prognostic outcomes in breast cancer patients.

Methods

A comprehensive computerized literature search was conducted across major Chinese and English databases to identify studies investigating the association between TK1 expression and breast cancer prognosis. Baseline TK1 expression levels and corresponding pat

SUBMITTER: Li P 

PROVIDER: S-EPMC12894012 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature