TsRNA-Ala-3-0030 drives ovarian cancer progression by suppressing ZNF70.

ABSTRACT: Globally, ovarian cancer remains a leading cause of gynecologic cancer death. This poor prognosis is primarily attributed to advanced disease at diagnosis, a high propensity for recurrence, and the inadequate therapeutic efficacy of current standard regimens. Emerging evidence has established the functional significance of transfer RNA-derived small RNAs (tsRNAs) in tumor biology. Nevertheless, their exact mechanisms and roles in ovarian cancer pathogenesis are not yet fully understood. Our research was designed to profile tsRNA expression, verify its presence in ovarian cancer tissues and established cell lines, and leverage cellular and animal models to decipher the functional roles and molecular mechanisms of these molecules. Our analysis revealed that tsRNA-Ala-3-0030 is significantly

SUBMITTER: Wang X 

PROVIDER: S-EPMC12894024 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature