Peripheral blood cytokine levels in paediatric-onset inflammatory bowel disease: A systematic review and meta-analysis.

ABSTRACT:

Objectives

We aimed to summarise findings on blood cytokine levels in patients with paediatric-onset inflammatory bowel disease (PIBD) compared to healthy controls.

Methods

This systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was registered at Prospero (CRD42024579684). A literature search was performed on 1 August 2024 in PubMed, EMBASE, Web of Science and Scopus. We included studies that reported levels of cytokines in plasma or serum. Pooled effect sizes of mean values were calculated using Hedges' g for any cytokine reported by two or more studies.

Results

The search revealed 5529 papers. Twenty-three articles reporting on 58 cytokines were included, totalling 1018 patients with PIBD

SUBMITTER: Jansson S 

PROVIDER: S-EPMC12894046 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature