Autoantibody signatures in children with celiac disease, juvenile idiopathic arthritis, and polyautoimmunity.

ABSTRACT:

Objective

To determine if multiplex autoantibody arrays can identify novel biomarker signatures in children with one or multiple autoimmune diseases (polyautoimmunity).

Methods

Plasma collected from children (18 years or younger) in the Boston Children's Hospital Precision Link Biobank for Health Discovery between January 2007 and June 2021 was analyzed using a microarray with 120 autoantigens associated with various autoimmune diseases to assess for both immunoglobulin G (IgG) and A (IgA) autoantibodies. To determine if disease-specific, we binary classified those with polyautoimmunity and the most common autoimmune diseases in our cohort (autoimmune thyroid disease, type 1 diabetes, or celiac disease [CeD]). For each comparison within and between groups, the autoantibody i

SUBMITTER: Du N 

PROVIDER: S-EPMC12894067 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature