Diversity of Aromatic Aldehyde Dehydrogenases in Ceriporiopsis subvermispora: Insights into Fungal Vanillin Metabolism.

ABSTRACT: Lignin-derived aromatic aldehydes are key intermediates in lignocellulosic biomass degradation but can exert cytotoxic effects on microorganisms. Ceriporiopsis subvermispora exhibited enhanced glucose consumption and mycelial growth when cultured in the presence of vanillin, suggesting its ability to metabolize lignin-derived aldehydes. We identified 16 putative aldehyde dehydrogenase genes (Cs-aldhA-P) from C. subvermispora, based on sequence homology to known aromatic aldehyde dehydrogenases (Pc-ALDH1 and Pc-ALDH2) from Phanerochaete chrysosporium. These Cs-Aldhs shared 65.7-89.7% amino acid identity with Pc-ALDHs and contained conserved functional motifs. They were grouped into six clades based on phylogenesis and AlphaFold2-based structural analyses, with pronounced divergence in the a

SUBMITTER: Lee J 

PROVIDER: S-EPMC12894122 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature