Cerium oxide nanoparticles attenuate hepatic failure via blocking TGF-β/Smads and upregulating Nrf2/HO-1 signaling pathways in liver fibrosis rat model.

ABSTRACT: T his article is aimed at assessing the anti-fibrotic action of plant-based fabricated cerium oxide nanoparticles (CeO₂NPs). The Carissa carandas aerial parts methanolic extract was utilized to prepare CeO₂NPs, where the dispersal of particle size distribution and zeta potential value was 61.9 nm and - 18.94 mV, respectively, verifying the successful synthesis of CeO₂NPs. In rats, CeO₂NPs were intravenously injected at doses of 0.1 and 0.5 mg/kg twice a week for a month, in parallel with thioacetamide (TAA, 200 mg/kg, i.p). Our findings revealed that CeO₂NPs alleviated the alteration in serum GPT, GOT, ALP, total bilirubin, albumin, and total protein levels induced by TAA. Additionally, the hepatic oxidative insult due to TAA was infer

SUBMITTER: Mowaad NA 

PROVIDER: S-EPMC12894128 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature