Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment.

ABSTRACT: Sorting endosomes and the endocytic recycling compartment are critical intracellular stores for the rapid recycling of internalized membrane receptors to the cell surface in multiple cell types. However, the molecular mechanisms distinguishing fast receptor recycling from sorting endosomes and slow receptor recycling from the endocytic recycling compartment remain poorly understood. We previously reported that Rab15 differentially regulates transferrin receptor trafficking through sorting endosomes and the endocytic recycling compartment, suggesting a role for distinct Rab15-effector interactions at these endocytic compartments. In this study, we identified the novel protein Rab15 effector protein (REP15) as a binding partner for Rab15-GTP. REP15 is compartment specific, colocalizing with

SUBMITTER: Strick DJ 

PROVIDER: S-EPMC1289414 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature