Tranexamic acid for spontaneous intracerebral hemorrhage: hematoma control without clinical benefits? A meta-analysis of RCTs.

ABSTRACT: Spontaneous intracerebral hemorrhage (sICH) is a serious form of stroke associated with high mortality and poor functional outcomes. Hematoma expansion critically affects prognosis, necessitating early intervention. Tranexamic acid (TXA), an antifibrinolytic, has an uncertain role in sICH. This meta-analysis synthesizes evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of TXA in sICH. Comprehensive searches of PubMed, Scopus, Web of Science, and Cochrane Library identified RCTs comparing intravenous TXA to placebo in sICH, focusing on hematoma expansion. Data on functional outcomes, mortality, thromboembolic events, and quality of life were extracted. Cochrane RoB2 assessed the quality of studies. RevMan 5.4 was used for data analysis, employing fixed-ef

SUBMITTER: Elhady MM 

PROVIDER: S-EPMC12894203 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature