Sitz bath with different concentrations of diluted povidone-iodine for prevention of perianal infection in patients with hematological malignancies undergoing chemotherapy: a randomized controlled trial in a tertiary hospital in China.

ABSTRACT:

Background

The incidence of perianal infection in patients with hematologic malignancies undergoing chemotherapy can reach 40-50%. Despite advances in medical technology and improved management strategies, the rate of perianal infection following chemotherapy remains substantial. Currently medicated sitz baths are not widely adopted in clinical practice due to their side effects and limited applicability. Povidone-iodine (PI) is a commonly used clinical broad-spectrum antiseptic, yet its efficacy in preventing perianal infection has not been adequately studied. Therefore, we aimed to evaluate the effect of different concentrations of diluted povidone-iodine in sitz baths on the incidence and severity of perianal infection, and to determine an appropriate concentration that minimize

SUBMITTER: Luo Y 

PROVIDER: S-EPMC12894220 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature