<i>Candidatus</i> Liberibacter asiaticus encodes a functional BolA transcriptional regulator related to motility, biofilm development, and stress response.

ABSTRACT: "Candidatus Liberibacter asiaticus" (CLas) is an uncultivable α-proteobacterium causing the most destructive and currently incurable citrus disease, Huanglongbing (HLB). The transcription factors (TFs) of CLas are involved in various biological processes. However, the functions of most TFs remain unverified. BolA is reported to be an important transcriptional regulator related to bacterial growth and virulence. Here, the role of BolA in CLas was investigated using gene deletion and complementation assays in the heterologous host Sinorhizobium meliloti (Sme). The results showed that BolA _CLas and BolA_Sme are similar in sequence and transcriptional regulation. BolA positively regulates biofilm formation-evidenced by the signific

SUBMITTER: Zhan X 

PROVIDER: S-EPMC12894273 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature