Periorbital skin index as a biomarker for biological aging and health status.

ABSTRACT:

Background

The periorbital skin area is particularly susceptible to aging compared to other facial regions due to its unique anatomical features and frequent muscle movements. This leads to early development of wrinkles and discoloration, which affect one's appearance. Because of these characteristics, the eye-region skin serves as a representative indicator reflecting both skin aging and overall health status.

Objectives

This study aims to develop and validate a straightforward, non-invasive method to evaluate changes in the eye-region skin as reliable markers of aging and overall physiological condition.

Methods

We analyzed facial images from 2,515 Korean women aged 20-69 and evaluated various periorbital features, including wrinkles, morphological characteristics,

SUBMITTER: Gu KN 

PROVIDER: S-EPMC12894317 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature