Making the invisible visible: integrated visualization and automated quantification of thrombus deformation during mechanical thrombectomy.

ABSTRACT:

Background

Mechanical thrombectomy using stent retrievers is a proven treatment for large vessel occlusion stroke, but quantitative and objective evaluation of device-thrombus interaction remains limited.

Objective

This study introduces a novel algorithm and experimental framework to visualize and quantify thrombus deformation during retrieval under standardized in vitro conditions, with the long-term goal of informing future clinically applicable analysis tools.

Methods

An in vitro model simulating large vessel occlusion was developed using organized human thrombi. Two stent retrievers - the Embotrap III (6.5 × 45 mm) and NeVa (4.5x 29 mm) - were studied in a vascular model under fluoroscopic guidance. An algorithm was developed to automatically segment

SUBMITTER: Ernst M 

PROVIDER: S-EPMC12894324 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature