Impact of low-dose sufentanil on the effective sedative dose of ciprofol for BIS-guided induction in elderly patients: an up-and-down sequential allocation trial.

ABSTRACT:

Objective

This study aimed to evaluate the effect of a single low dose of sufentanil on the effective dose of ciprofol required to achieve a bispectral index (BIS) <60 during anesthesia induction in elderly patients.

Methods

A total of 48 elderly patients were randomly assigned to either the sufentanil plus ciprofol group (S + C group) or the ciprofol alone group (C group). A sufentanil dose of 0.1 μg/kg was administered to the S + C group (diluted to 5 ml), while the C group was administered 5 ml of normal saline. Five minutes later, the initial administration for both groups was 0.3 mg/kg ciprofol. Subsequent doses were adjusted in increments or decrements of 0.05 mg/kg according to the response of the preceding patient within the same treatment group, following two indepe

SUBMITTER: Han Q 

PROVIDER: S-EPMC12894343 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature