Synergistic bactericidal activity of a ginsenoside-copper nano-agent against gram-positive and gram-negative biofilm bacteria.

ABSTRACT:

Background

Biofilm-associated infections pose a formidable challenge due to their high tolerance to conventional antibiotics. While copper-based therapies offer a promising avenue, their clinical utility is severely limited by non-specific cytotoxicity and rapid deactivation. To address this, we engineered an intelligent, redox-responsive nanoplatform composed of Ginsenoside Re (GS) and copper (Cu²⁺), termed GSR NPs.

Methods

GSR NPs were synthesized through a facile self-assembly process using GS and Cu²⁺. The nanoparticles were extensively characterized using microscopy and molecular dynamics simulations. Their physicochemical stability, redox-responsiveness, reactive oxygen species (ROS) generation, and antibacterial efficacy were evaluated against

SUBMITTER: Tan T 

PROVIDER: S-EPMC12894357 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature