Efficacy of reduced-intensity or no heparin versus standard heparin anticoagulation in patients on extracorporeal membrane oxygenation: a systematic review and meta-analysis.

ABSTRACT:

Objective

This study aims to evaluate the efficacy of reduced-intensity or no heparin anticoagulation strategy in comparison to standard anticoagulation strategy during extracorporeal membrane oxygenation (ECMO) support.

Materials and methods

Systematic literature review and meta-analysis, complying with the PRISMA guidelines (PROSPERO-CRD42025633878).

Results

Eleven studies comprising 958 patients were included in the analysis. Four studies included only patients treated with veno-venous extracorporeal membrane oxygenation (V-V ECMO) for acute respiratory distress syndrome or respiratory failure, two studies focused exclusively on patients treated with veno-arterial extracorporeal membrane oxygenation (V-A ECMO), and five studies included a mixture of patients with b

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12894395 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature