Tibia length is an appropriate standard for evaluating hypertrophy in streptozotocin-induced diabetic complications.

ABSTRACT: The pathogenesis of diabetic complications has been extensively studied in streptozotocin (STZ)-induced diabetic mice. Body weight (BW) is still used to standardize organ hypertrophy, but it may be unreliable due to significant weight loss in this model. This study aimed to assess the reliability of using tibia length (TL) as a common standard for organ hypertrophy in emaciated diabetic mice. Diabetes was induced by STZ in wild type mice with C57BL6/N (6N) and BL6/J (6J) background. TL and the weights of the heart (HW), kidneys (KW), and bladder (BLW) were estimated at 1-, 3-, and 6-month post-diabetes induction. The 6N mice were more sensitive to STZ than the 6J mice. In 1-month diabetic mice, the HW, HW/TL, and HW/TL³ ratios decreased in both substrains. In contrast, BLW/TL an

SUBMITTER: Qin M 

PROVIDER: S-EPMC12894438 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature